112

News

Danish research: COVID-19 patients can be saved by dampening immune system

Christian Wenande
August 4th, 2020


This article is more than 4 years old.

New study provides important knowledge to help patients with weakened lungs avoid succumbing to the virus

Quite a few have caught it twice (photo: Pixabay)

According to a new study at Aarhus University (AU), critically-ill COVID-19 patients can be saved by dampening their immune system.

The research showed that the immune system’s attempt to fight off COVID-19 weakens the lungs of patients to the point where they succumb to the virus.

When infected with COVID-19, the lungs of vulnerable patients are unable to repair damaged tissue, leading to death in many cases. As a result, reducing the immune system’s reaction to the coronavirus could help save lives.

“The immune system’s cytokines comprise a double-edged sword in these types of infections. The cells infected by the virus are prevented from growing and dividing, but unfortunately these cytokines have the same effect on the cells that do not contain viruses, such as those in the damaged lung tissue,” said Rune Hartmann, a professor at the Department of Molecular Biology and Genetics at AU.

“Our new results show that the damaged lung cells are therefore not repaired. The ideal treatment for people who are seriously ill with respiratory viruses is therefore to initially stimulate cytokines early during infection and then down-regulate them later to avoid killing the patient.” 

READ ALSO: Coronavirus experts: second wave expected in September

From mice to men
Even though the new study is conducted on mice with the influenza virus as a model organism, the researchers are confident that their observations also occur in humans.

The study, ‘Type I and III interferons disrupt lung epithelial repair during recovery from viral infection’, has been published in the scientific journal Science.

Read more about the findings here (in English).


Share

Most popular

Subscribe to our newsletter

Sign up to receive The Daily Post

















Latest Podcast

A survey carried out by Megafon for TV2 has found that 71 percent of parents have handed over children to daycare in spite of them being sick.

Moreover, 21 percent of those surveyed admitted to medicating their kids with paracetamol, such as Panodil, before sending them to school.

The FOLA parents’ organisation is shocked by the findings.

“I think it is absolutely crazy. It simply cannot be that a child goes to school sick and plays with lots of other children. Then we are faced with the fact that they will infect the whole institution,” said FOLA chair Signe Nielsen.

Pill pushers
At the Børnehuset daycare institution in Silkeborg a meeting was called where parents were implored not to bring their sick children to school.

At Børnehuset there are fears that parents prefer to pack their kids off with a pill without informing teachers.

“We occasionally have children who that they have had a pill for breakfast,” said headteacher Susanne Bødker. “You might think that it is a Panodil more than a vitamin pill, if it is a child who has just been sick, for example.”

Parents sick and tired
Parents, when confronted, often cite pressure at work as a reason for not being able to stay at home with their children.

Many declare that they simply cannot take another day off, as they are afraid of being fired.

Allan Randrup Thomsen, a professor of virology at KU, has heavily criticised the parents’ actions, describing the current situation as a “vicious circle”.

“It promotes the spread of viruses, and it adds momentum to a cycle where parents are pressured by high levels of sick-leave. If they then choose to send the children to daycare while they are still recovering, they keep the epidemic going in daycares, and this in turn puts a greater burden on the parents.”